Doxycycline post-exposure prophylaxis is effective and highly acceptable in an urban public sexually transmitted disease clinic: Philadelphia, 2019-2023.

ABSTRACT:

Background

We sought to determine real-world effectiveness of doxycycline post-exposure prophylaxis (doxy PEP) in reducing sexually transmitted infections (STI) among men who have sex with men attending an HIV pre-exposure prophylaxis (HIV PrEP) clinic in Philadelphia.

Methods

Data from eligible HIV PrEP patients who did and did not receive doxy PEP from September 1, 2019-December 31, 2023 were analyzed. We used a cohort study design and Cox models to estimate associations between doxy PEP receipt and incident gonorrhea (GC), chlamydia (CT), and/or syphilis. We also used a crossover design and Poisson models to estimate incidence rate ratios (IRR) for any STI and each STI separately among individuals in the year before and after doxy PEP initiation.

Results

Among the

SUBMITTER: Lewis FMT 

PROVIDER: S-EPMC12313191 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature