MIP3α-Rel_Mtb intranasal DNA vaccination induces reactive T-cell infiltration into the lungs of mice and macaques.

ABSTRACT: Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of mortality due to a single infectious organism. While generally curable, TB requires a lengthy and complex antibiotic regimen, due in large part to persistent bacteria that survive antibiotic exposure. Rel_Mtb is the primary enzyme regulating the stringent response, which contributes to Mtb persistence. Targeting Rel_Mtb with a vaccine to eliminate persistent bacteria in combination with antibiotics to kill dividing bacteria has shown promise in model systems. In a mouse model of Mtb infection, a vaccine created by genetically fusing rel_Mtb to the chemokine macrophage inflammatory protein 3α (MIP3α), a ligand for the CC chemokine receptor type 6 (CCR6) present o

SUBMITTER: Gordy JT 

PROVIDER: S-EPMC12313244 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature