No evidence of pitavastatin effect on muscle area or density among people with HIV.

ABSTRACT:

Background

Skeletal muscle area and muscle density are key determinants of physical function and typically decline with increasing age. Statins have well known musculoskeletal effects but whether statins impact muscle area or muscle density is not well established, especially in the setting of randomized treatment.

Methods

REPRIEVE is a double-blind randomized trial evaluating the effect of pitavastatin for primary prevention of major adverse cardiovascular events in people with HIV (PWH). Thoracic paraspinal, pectoralis, and infraspinatus muscle area and muscle density were assessed among Mechanistic Substudy participants with CT at baseline and month 24.

Results

Of 804 substudy participants, 510 remained on study treatment and had imaging at baseline and month 24. M

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC12313271 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature