The Therapeutic Effects of Purified Cortrophin Gel on Experimental Autoimmune Uveitis.

ABSTRACT:

Purpose

The melanocortin pathways are central in maintaining the normal anti-inflammatory microenvironment of the eye. A repository corticotropin injection (RCI) from ANI Pharmaceuticals that activates multiple melanocortin pathways was studied for its effects on experimental autoimmune uveitis (EAU), a murine model of human endogenous uveitis.

Methods

At the chronic phase of EAU, the mice received an injection of the RCI. Clinical scoring of the eyes was conducted every 3 to 4 days using fundus microscopy until the uveitis resolved. The eyes were collected, sectioned, and H&E stained for histological scoring. A T-cell reaction assay was performed using spleen cells to measure IFN-g, IL-17, and IL-10 following restimulation with retinal antigen. The effects of the RCI's acti

SUBMITTER: Taylor AW 

PROVIDER: S-EPMC12313274 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature