Pro-Inflammatory Response to Macrotextured Silicone Implant Wear Debris.

ABSTRACT: Macrotextured silicone breast implants are associated with several complications, ranging from seromas and hematomas to the formation of a rare type of lymphoma, known as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The presence of silicone wear debris has been detected within the peri-implant region and fibrotic capsule and histological analyses reveal inflammatory cells surrounding debris particles. However, it is unclear how these debris particles are generated and released from macrotextured implant surfaces, and whether wear debris generation is related to implant stiffness. In this study, we created an accelerated implant aging model to investigate the formation of silicone wear debris produced from self-mated ("shell-shell") tribological interactions. We crea

SUBMITTER: Atkins DJ 

PROVIDER: S-EPMC12313313 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature