Free carbenes from complementarily paired alkynes.

ABSTRACT: Carbenes (R¹R²C:) like radicals, arynes and nitrenes constitute an important family of neutral, high-energy, reactive intermediates-fleeting chemical entities that undergo rapid reactions. An alkyne (R³C≡CR⁴) is a fundamental functional group that houses a high degree of potential energy; however, the substantial kinetic stability of alkynes renders them conveniently handleable as shelf-stable chemical commodities. The ability to generate metal-free carbenes directly from alkynes, fuelled by the high potential (that is, thermodynamic) energy of the latter, would constitute a considerable advance. We report here that this can be achieved simply by warming a mixture of a 2-alkynyl iminoheterocycle (a cyclic compound containing a nucleophilic nitrog

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12313361 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature