Development of a ribavirin dosing regimen in transplant recipients with chronic hepatitis E virus infection: a population pharmacokinetic and -dynamic model.

ABSTRACT:

Objectives

The optimal ribavirin dosing regimen for the treatment of chronic hepatitis E virus (HEV) infection in solid organ transplant (SOT) is unknown. We modelled ribavirin plasma concentrations versus virologic response and haemoglobin concentrations.

Patients and methods

Data were collected in a retrospective, multicentre study of adult SOT recipients with chronic HEV infection treated with ribavirin between September 2009 and November 2019. Population pharmacokinetic and pharmacodynamic analyses were conducted using nonlinear mixed-effects modelling. Simulations were performed to select the most suitable RBV dosing regimen considering efficacy and safety.

Results

In total, 107 chronically HEV-infected SOT recipients with 305 ribavirin plasma levels, 592 viral l

SUBMITTER: Mulder MB 

PROVIDER: S-EPMC12313452 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature