The impact of inter-infection time on antimicrobial resistance profiles in women with multiple urinary tract infections over time.

ABSTRACT:

Background

Urinary tract infection (UTI) treatment in primary care is increasingly complicated by antimicrobial resistance (AMR), and antimicrobial susceptibility profiles are rarely available to prescribers at the point of prescription. Susceptibility profiles from previous urine culture results could inform prescribing, but little is known about associations between previous and current susceptibilities and the impact of time between infections (inter-infection time) on these associations.

Methods

We analysed routinely collected healthcare records of women ≥16 years in Oxfordshire, UK, who had two or more culture-positive urine specimens consistent with a UTI between 2013 and 2019. We used generalized additive logistic models to estimate associations between resistance to

SUBMITTER: Honda T 

PROVIDER: S-EPMC12313461 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature