Indolocarbazoles as host-directed therapeutics against intracellular infections by methicillin-resistant Staphylococcus aureus.

ABSTRACT:

Background and objectives

Methicillin-resistant Staphylococcus aureus (MRSA) is a principal contributor to mortality and morbidity attributable to antimicrobial resistance. Many MRSA strains are able to invade host cells, thereby further evading antibiotic treatment. Previously, indolocarbazole GW296115X was identified as a hit compound with host-directed activity against intracellular MRSA. This study evaluates the efficacy and selectivity of indolocarbazoles as potential host-directed therapy against intracellular MRSA. Furthermore, we assessed the interaction between indolocarbazoles and standard-of-care antibiotics.

Methods

Bioluminescent luxBADCE-expressing MRSA was used to evaluate antimicrobial activity in planktonic cultures and HeLa cell intracellular infection mode

SUBMITTER: van den Biggelaar RHGA 

PROVIDER: S-EPMC12313463 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature