Association between the dietary index for gut microbiota and frailty: the mediating role of body mass index.

ABSTRACT:

Background

The Dietary Index for Gut Microbiota (DI-GM), a newly introduced metric, indicates gut microbiota diversity. However, its correlation with frailty remains unexplored.

Method

A total of 25,320 individuals were included in the 2007-2020 National Health and Nutrition Examination Survey (NHANES). Dietary recall data were calculated by averaging intake values from two separate 24-h dietary recall interviews. Frailty was assessed using the 49-item frailty index. The relationship between DI-GM and the frailty phenomenon was examined by applying a weighted logistic regression model. A comprehensive sensitivity analysis was undertaken, incorporating restricted cubic splines for modeling non-linear effects, stratified subgroup analyses to explore effect modification, and mu

SUBMITTER: Lei J 

PROVIDER: S-EPMC12313513 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature