Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.

ABSTRACT:

Background

Sarcopenia, an age-related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. Nucleotides (NTs) supplementation is a potential strategy for preventing age-related sarcopenia as evidence suggests that NTs declined in muscles with aging, and 5'-CMP, 5'-UMP can mitigate muscle atrophy in C2C12 myotubes. This study aimed to investigate the effects of NTs supplementation on sarcopenia and its possible mechanism.

Methods

Senescence-accelerated mouse prone-8 (SAMP8) mice and C2C12 cells were used to assess the effect of NTs on sarcopenia. We fed an NTs-enriched mixture to SAMP8 mice starting from the age of 3 months for 9 months or 15 months. NTs' effects on H₂O₂-induced C2C12 at

SUBMITTER: Wu X 

PROVIDER: S-EPMC12313545 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature