Cu/Zn superoxide dismutase homologs participate in <i>Nicotiana benthamiana</i> antiviral responses.

ABSTRACT: Superoxide dismutases (SODs) serve as the first line of defense against reactive oxygen species. Copper-zinc superoxide dismutase (Cu/Zn-SOD) is an enzyme whose activity depends on copper availability. Cu/Zn-SOD-1 induction is shown to be involved in the antioxidative and antiviral activity of acetylsalicylic acid in hepatitis C virus (HCV)-expressing cells. Here, RNA sequencing (RNA-seq) analysis identified SOD homologs (three NbCu/Zn-SOD, four NbFe-SOD, and two NbMn-SOD) that were differentially expressed in Nicotiana benthamiana during tobacco vein mottling virus (TVMV) infection. NbCu/Zn-SOD-1 was cloned from N. benthamiana and subsequently characterized. Encoding sequence and structural analyses of the NbCu/Zn-SOD-1 protei

SUBMITTER: Wang H 

PROVIDER: S-EPMC12313585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature