A porcine model of acute rejection for cardiac transplantation.

ABSTRACT: Ex vivo machine perfusion has been growing in utility for preserving donor organs prior to transplantation. This modality has tremendous potential for bioengineering and conditioning organs prior to transplantation using small molecule or advanced therapeutics. To safely translate potential interventions, well characterized models of disease are crucial for testing the therapeutic and possible side effects that could manifest from the interventions. Acute cellular rejection remains a significant complication in organ transplantation that affects transplant recipients with significant morbidity and mortality. This disease could potentially be mitigated with therapeutic intervention during ex vivo machine perfusion. A porcine animal model of acute rejection could be characteriz

SUBMITTER: Mendiola Pla M 

PROVIDER: S-EPMC12313652 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature