Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly.

ABSTRACT: Apoptosis has been shown to play an important role in the treatment of gastric cancer, and BCL2-associated athanogene 2(BAG2) has been found to be able to inhibit apoptosis by interacting with multiple apoptosis regulators. In this study, we demonstrate that BAG2 functions as an independent prognostic factor, correlating with unfavorable clinical outcomes in patients with gastric cancer (GC). We demonstrate that BAG2 upregulation inhibited apoptosis and increased proliferation, migration, and invasion of GC cells, whereas the opposite results were obtained in BAG2-deficient GC cells. Mechanistically, BAG2 interacts with the c-terminus of HSP70-interacting protein(CHIP) to inhibit the ubiquitination degradation of Heat shock protein70(HSP70) and increase the binding of HSP70 to apoptotic pr

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12313710 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature