The myth of iodine: A systematic review and meta-analysis on the relationship between iodine and thyroid nodule.

ABSTRACT:

Background

Iodine is an essential trace element for thyroid hormone synthesis, and its role in thyroid health has been widely studied. While iodine deficiency is recognized as a risk factor for goiter, its association with thyroid nodules remains controversial. The aim of this systematic review and meta-analysis was to evaluate the relationship between iodine intake and the development of thyroid nodules.

Methods

A systematic literature search was conducted in Medline (via PubMed), the Cochrane Library, and guideline registries (AWMF, GIN) for studies published between 2012 and 2023. Inclusion criteria focused on studies examining the association between iodine intake and thyroid nodule. Systematic review has been conducted whereas study quality was assessed using the checkl

SUBMITTER: Grafe W 

PROVIDER: S-EPMC12313809 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature