Normalization of elevated preoperative serum creatinine and acute kidney injury after cardiac surgery: a retrospective cohort study.

ABSTRACT: Preoperative kidney dysfunction is a predictor of acute kidney injury (AKI) following cardiac surgery, limited information exists regarding the impact of preoperative serum creatinine (sCr) change on AKI. This study aims to examine the association between the normalization of elevated preoperative sCr and postoperative AKI, as well as its severity and duration. This retrospective cohort study included patients undergoing open-heart surgery. Patients were categorized into three groups based on preoperative sCr change (ΔScr): the Stable sCr group (maximum ΔScr < 0.3 mg/dL throughout the preoperative period), the Normalized sCr group (maximum ΔScr ≥ 0.3 mg/dL followed by normalization to < 0.3 mg/dL within 48 h pre-surgery), and the Worsened sCr group (maximum ΔScr ≥ 0.3 mg/dL, remaining ≥ 0.

SUBMITTER: Jiang B 

PROVIDER: S-EPMC12313847 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature