Deciphering anti-colorectal cancer potential of Avicennia alba bioactives via network pharmacology and in vitro validation.

ABSTRACT: Colorectal cancer (CRC) remains a significant global health challenge, with the current therapies often being inadequate. This study investigates the potential of Avicennia alba (A. alba), a mangrove plant, as a source of new anticancer drug candidates. We employed a network pharmacology, bioinformatics approach, and in vitro experimental to explore the molecular mechanisms of action and validating activity of A. alba in CRC treatment. Cytotoxicity effect was also evaluated using MTT assay. Four constituents of A. alba-Avicenol B, Avicenol C, Avicequinone B, and Avicequinone C-were verified, leading to the identification of 10 hub genes (i.e., EGFR, PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC. Molecular docking and molecular dynamics simulations indicate

SUBMITTER: Irham LM 

PROVIDER: S-EPMC12313873 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature