Folate-based binuclear Mn(II) chelates with 2,2'-bipyridine/1,10-phenanthroline as targeted anticancer agents for colon cancer cells.

ABSTRACT: Researchers have shown significant interest in the chemistry of mixed ligand transition metal chelates due to their diverse applications and bonding features. Herein, we have reported the synthesis of two new binuclear Mn(II) chelates with the composition of [Mn₂(FA)(Bpy)₂(H₂O)₂Cl₂].7H₂O (Chelate 1) and [Mn₂(FA)(Phen)₂(H₂O)₂Cl₂].7H₂O (Chelate 2) (where, FA = folate anion, Bpy = 2,2'-bipyridine, Phen = 1,10-phenanthroline). The folate anion acts as a bridging ligand to obtain the binuclear complexes with the suggested composition. The chelates have been characterized by using elemental analysis, spectroscopic (FTIR, UV-vis), EI-MS and TGA techniques. Further, t

SUBMITTER: Ragab MS 

PROVIDER: S-EPMC12313882 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature