PRMT1-mediated methylation of UBE2m promoting calcium oxalate crystal-induced kidney injury by inhibiting fatty acid metabolism.

ABSTRACT: Calcium oxalate (CaOx) is the most common type of kidney stone, and its crystal deposition can induce oxidative stress, inflammatory responses, and cell death. This further aggravates kidney structural and functional damage, which in turn, promotes kidney stone recurrence, forming a vicious cycle of repeated stone formation and renal injury. Therefore, identifying precise and effective therapeutic targets is crucial to prevent the damage and inflammation caused by kidney stones. Protein arginine methyltransferase 1 (PRMT1) is a well-known epigenetic regulatory enzyme involved in renal metabolic reprogramming. However, the role of PRMT1-mediated arginine methylation in kidney stone-induced renal injury remains unclear. In this study, mice with specific deletion or overexpression of PRMT1 in

SUBMITTER: Yuan T 

PROVIDER: S-EPMC12313907 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature