Sex-specific DNA methylation associations with circulating urate levels and BCG-induced urate changes.

ABSTRACT:

Background

Urate concentration and the physiological regulation of urate homeostasis exhibit clear sex differences. DNA methylation has been shown to explain a substantial proportion of serum urate variance, mediate the genetic effect on urate concentration, and co-regulate with cardiometabolic traits. However, whether urate concentration is associated with DNA methylation in a sex-dependent manner is unknown. Additionally, it is worth investigating if urate changes after perturbations, such as vaccination, are associated with DNA methylation in a sex-specific manner.

Methods

We investigated the association between DNA methylation and serum urate concentrations in a Dutch cohort of 325 healthy individuals. Urate concentration and DNA methylation were measured before and afte

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12313909 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature