Maternal parity modifies the association of birthweight polygenic score with fetal growth.

ABSTRACT: Low birthweight is more common among children born to nulliparas (women with no prior pregnancy lasting ≥20 weeks of gestation) compared to those born to multiparas (women with one or more prior pregnancies lasting ≥20 weeks). We investigated whether parity modifies the association of maternal genetic risk score (mGRS) of maternal birthweight-reducing genetic variants with fetal size and weekly growth pace (i.e., change in fetal size over a 1-week gestational age interval) at gestational weeks 10-40 in two multi-ancestral cohorts of pregnant women. mGRS, derived from previously identified birthweight-reducing maternal variants was tested for association with fetal size and weekly growth pace using linear regression adjusted for fetal sex and top 10 genetic principal components. Among nulli

SUBMITTER: Wijesiriwardhana P 

PROVIDER: S-EPMC12313924 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature