Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing.

ABSTRACT: Effective wound repair is critically impaired by persistent inflammatory responses and oxidative damage, which collectively impede tissue regeneration and exacerbate fibrotic scarring. To overcome these dual barriers, we engineered a multifunctional hydrogel platform, designated KGM-GA/XG-DPA (KG-XD^gel), through molecular integration of gallic acid-conjugated konjac glucomannan (KGM-GA) with dopamine-modified xanthan gum (XG-DPA). This biomaterial system demonstrates dual therapeutic modalities: (1) concurrent scavenging of reactive oxygen species (ROS) via synergistic redox activity from phenolic components (gallic acid and catechol moieties), and (2) targeted immunomodulation through carbohydrate-mediated engagement of CD206 receptors to drive M2 macrophage polarization. Enhan

SUBMITTER: Li H 

PROVIDER: S-EPMC12313959 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature