TIPE2 combined with immune cell infiltration predicts prognosis in colorectal cancer.

ABSTRACT: The incidence of colorectal cancer has shown an obvious upward trend worldwide. The prognostic prediction of CRC has not been well established. Based on immunohistochemistry staining, the expression and scoring of TIPE2 and CD8, CD20, and CD66b were evaluated and grouped. The clinicopathological parameters and IHC scores were analyzed and showed by Kaplan-Meier plots. High TIPE2 expression in CRC and normal tissues correlated with a better OS. In contrast, high CD8 and CD20 expression in CRC and normal tissues correlated with a worse OS. High CD66b expression in normal tissues was associated with a worse OS. Lasso and Cox analysis showed that N-stage, CA199, and CD8 in adjacent normal tissues were independent risk factors for OS. Grade and TIPE2 expression in cancer tissues were independen

SUBMITTER: Xia H 

PROVIDER: S-EPMC12313966 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature