RpoB mutation patterns in Rifampicin-resistant tuberculosis: a Jiangxi Province study, 2021-2023.

ABSTRACT: Antimicrobial resistance in Mycobacterium tuberculosis (M.tb) strains presents a significant challenge to global tuberculosis (TB) control efforts. This study was conducted to explore the distribution and prevalence of mutations at various sites within the 81 bp Rifampicin (RIF) resistance-determining region (RRDR) of the rpoB gene in M.tb, as detected by the Xpert MTB/RIF assay. This retrospective analysis encompassed 9,867 non-repeating patients diagnosed with TB between 2021 and 2023. Cases with RR detected by the Xpert were included in further detailed analysis. The study utilized Chi-square tests or Fisher's exact tests to identify statistically significant differences in demographic variables and the prevalence of rpoB gene mutations between RResistant TB (RR-TB) and non-RR-TB groups

SUBMITTER: Mao ZQ 

PROVIDER: S-EPMC12313984 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature