The impact of prematurity on pediatric asthma morbidity and indices with environmental pollution and genetic susceptibility.

ABSTRACT:

Background

Prematurity, fine particulate matter (PM_2.5), and genetic variables are linked to asthma incidence in children. However, to capture the contributions of these variables and their involvement in asthma pathogenesis, we need to understand how they interact. Here, we aim to assess the impact of prematurity on asthma exacerbations and explore interactions with PM_2.5 exposure and genetic risk.

Methods

Pediatric patients with asthma and at least 5 years of follow-up data were identified from the Center for Applied Genomics biobank. Subjects were classified as full term (FT), late preterm (LPT), or extremely/very preterm (E/VPT). PM_2.5 exposure was calculated as the proportion of days between diagnosis and last recorded follow up exceedin

SUBMITTER: Kelchtermans J 

PROVIDER: S-EPMC12314037 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature