The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner.

ABSTRACT: Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by chronic inflammation, barrier impairment, and immunoglobulin E-mediated sensitization. Sodium dodecyl benzene sulfonate (SDBS) is a widely used anionic surfactant which are believed to exacerbate AD according to the hygiene hypothesis. However, recent studies have shown that SDBS does not significantly upregulate the expression of key proinflammatory cytokines, which is inconsistent with previous hypotheses. Furthermore, it is not known whether SDBS affect the inflammatory response to AD. Herein, we used mice with MC903-induced AD-like dermatitis and tumor necrosis factor (TNF)-α/interferon (IFN)-γ (T/I)-treated HaCaT cells to investigate the effects of SDBS on AD. We found that topical use of 0.1% and 1%

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12314043 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature