Pulmonary Vasodilator Therapy in Patients With Fontan Circulation: A Meta-Analysis.

ABSTRACT:

Background and objectives

The effect of pulmonary vasodilator therapy on patients with Fontan circulation remains unclear. This study aims to assess its impact on exercise capacity and hemodynamic parameters in this population.

Methods

We searched PubMed, Embase, and the Cochrane Library for relevant studies up to November 2023. Pooled outcomes were used to evaluate the efficacy of pulmonary vasodilators in Fontan patients.

Results

A total of 18 studies with 667 patients were included. Exercise capacity was assessed in 14 studies (526 patients). Pulmonary vasodilator therapy improved oxygen consumption anaerobic threshold (VO₂AT; MD, 1.12 mL/min/kg; 95% CI, 0.35 to 1.89; p=0.004) and Ve/VCO₂ slope (MD, -1.14; 95% CI, -1.97 to -0.31; p=0.007) during exercise. No signif

SUBMITTER: Cho MJ 

PROVIDER: S-EPMC12314064 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature