Advanced 4-chamber echocardiography techniques enable clinically matched precise characterization of heart disease progression in mice.

ABSTRACT:

Background

Transthoracic echocardiography remains the primary non-invasive method for assessing cardiac function in clinical practice. However, technical challenges in acquiring accurate apical 4-chamber-long-axis (A4CLAX) views have historically limited mouse studies to left ventricle (LV) assessment using parasternal short-axis (SAX) M-mode imaging.

Methods

To overcome this limitation, we developed an A4CLAX imaging approach for mice and performed a comparative analysis with established echocardiographic methods to assess cardiac function in healthy mouse hearts. To evaluate the utility of A4CLAX in detecting disease progression, we longitudinally monitored cardiac function of C57BL/6 N mice (male and female) following severe transverse aortic constriction (TAC), using bot

SUBMITTER: Kacira E 

PROVIDER: S-EPMC12314085 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature