Country-level incidence of Alzheimer disease and related dementias is associated with increased omega-6-PUFA consumption.

ABSTRACT:

Background

Clinical and genetic studies have implicated lipid dysfunction in Alzheimer Disease (AD) pathogenesis. While the etiologic impact of lipid intake on individuals is receiving attention, the role of food systems in shaping community-level incidence remains uncharacterized.

Methods

Mean country-level lipid intakes were compared to Age-Standardized Alzheimer-and-other-Dementia Incidence Rates (ASAIR) in 183 countries across all inhabited continents. Free-knot penalized spline regression and multivariable-adjusted linear regression, including a lag between intake and incidence, were used to assess the relationships between five lipid intakes and ASAIR. Validation was conducted using longitudinal within-country changes between 1990 and 2019.

Results

Here we show

SUBMITTER: Ciesielski TH 

PROVIDER: S-EPMC12314086 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature