A new Drosophila model of prolonged inactivity shortens lifespan and impairs muscle function.

ABSTRACT: Prolonged inactivity due to medical conditions can cause chronic muscle disuse and lead to physical incapacity and poor quality of life. Here, we developed a Drosophila model of confinement inactivity (CI) to observe its effects on lifespan and muscle function. We found that, similar to mammalian models and humans, CI negatively impacted longevity and function in Drosophila. Confined flies had impaired mobility, shorter lifespan, and reduced muscle integrity compared to their freely mobile siblings. These findings establish a new, highly efficient platform for studying long term effects of chronic sedentary behavior and muscle disuse in the genetically tractable Drosophila model. In addition, we found that temporarily removing flies from CI for scheduled bouts of forced physical exercise a

SUBMITTER: Protasiewicz J 

PROVIDER: S-EPMC12314096 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature