Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma.

ABSTRACT:

Background

Radiological imaging plays an indispensable role in both preclinical and clinical studies of multiple myeloma (MM). However, manual quantification in longitudinal small animal PET/CT is limited by annotator bias, signal artifacts from urinary/fecal excretion, and voxel misalignment due to non-rigid registration. To address these challenges and improve characterization of tumor biology, we developed a semi-automated PET/CT quantification pipeline targeting defined regions of interest (ROIs) within the bone marrow-rich mouse skeleton, achieving sub-organ spatial resolution, including in anatomically complex sites such as the pelvis. We applied this MM-specific preclinical pipeline to analyze tumor distribution in a longitudinal molecular PET study using an immunocompetent

SUBMITTER: Sun Z 

PROVIDER: S-EPMC12314142 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature