Multi-institution longitudinal apparent diffusion coefficient measurements in a diffusion weighted imaging phantom at room temperature.

ABSTRACT:

Background and purpose

This work contributes to technical validation of apparent diffusion coefficient (ADC) as a biomarker of cancer. The aim was to evaluate ADC accuracy, random error, short-term and long-term repeatability and reproducibility, across multiple institutions using a room temperature phantom.

Materials and methods

ADC measurements were made in a travelling room temperature diffusion weighted imaging (DWI) phantom on six scanners at four UK institutions over 18 months at six-month intervals. ADC bias measurements were calculated as the difference between measured and temperature corrected ground-truth ADC values and used to calculate mean ADC bias, isocentre ADC error estimate, short- and long-term intra-scanner repeatability as per the Quantitative Imaging Bi

SUBMITTER: Moore C 

PROVIDER: S-EPMC12314170 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature