Neuropathological correlations of ¹⁸F-florzolotau PET in a case with pick's disease.

ABSTRACT:

Background

Pick's disease (PiD) is classified as frontotemporal lobar degeneration with pathological tau aggregates. Positron emission tomography (PET) with ¹⁸F-florzolotau provides high-contrast imaging of diverse tau fibrils. While our previous work demonstrated the detectability of three repeat (3R) tau pathology by ¹⁸F-florzolotau PET in an autopsy-confirmed PiD patient, its potential for quantitative assessment of 3R tau aggregates in living individuals remains unclear. In this study, we analyzed correlations between in vivo ¹⁸F-florzolotau retentions and postmortem neuropathological data across brain regions in the same case with PiD.

Case presentation

The patient was 60 years of age at the time of death and had been diagnosed with beha

SUBMITTER: Suzuki H 

PROVIDER: S-EPMC12314175 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature