Association of T-Cell Profiles With Disease Severity, Drug-Induced Liver Injury, and Treatment Completion in Tuberculosis.

ABSTRACT:

Background

Tuberculosis (TB) treatment is challenged by a long duration, poor adherence, and the high risk of drug-induced liver injury (DILI). T-cell immunity is essential for anti-mycobacterial defense, but current immune-monitoring methods poorly reflect disease severity and treatment response. Correlations of immune subpopulations with TB severity, DILI, and treatment prognosis remain poorly understood.

Methods

Peripheral blood mononuclear cells were collected from confirmed TB patients (n = 40). Multiparameter flow cytometry analysis was used to assess previously defined TB-associated T-cell phenotypes based on the co-expression of cytokines and immune checkpoint molecules following stimulation with two Mycobacterium tuberculosis peptides: culture filtrate protein 10 an

SUBMITTER: He Y 

PROVIDER: S-EPMC12314307 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature