Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial.

ABSTRACT:

Background

Treatments aimed at improving physical function and body composition, including reducing fat mass (FM) and increasing muscle mass, may benefit individuals with advanced knee osteoarthritis (OA) and obesity. We investigated the feasibility and efficacy of a multimodal behavioural intervention compared to usual care to enhance physical function and muscle mass in this population.

Methods

The POMELO (Prevention Of MusclE Loss in Osteoarthritis) study is a two-arm pilot randomized controlled trial; NCT05026385. Participants aged 40-75 years, with a BMI ≥ 35 kg/m² and knee OA were randomized 1:1 to either the intervention group (POMELO) or usual care (UC). The 3-month POMELO intervention incorporated progressive resistance exercise (3 sessions/week), individ

SUBMITTER: Godziuk K 

PROVIDER: S-EPMC12314308 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature