Enhanced Cerenkov radiation induced photodynamic therapy based on GSH-responsive biomimetic nanoplatform to trigger immunogenic cell death for tumor immunotherapy.

ABSTRACT: Cerenkov radiation (CR) can serve as a source of internal light to overcome the limited tissue penetration of external light in conventional photodynamic therapy (PDT). However, insufficient luminescence intensity hinders the clinical application of CR-PDT. Here, we developed a glutathione-responsive biomimetic nanoplatform by fusing cancer cell membranes and liposomes loaded with photosensitizer hematoporphyrin monomethyl ether (HMME) and a radiation energy amplifier Eu³⁺, named HMME-Eu@LEV. Colloidal Eu³⁺ converts γ-radiation and CR from radioisotopes into fluorescence to enhance anti-tumor effects. Sequential administration ensures co-localization of HMME-Eu@LEV and radiopharmaceutical ¹⁸F-fluorodeoxyglucose (FDG) at the tumor site, triggering enhanced C

SUBMITTER: Qian R 

PROVIDER: S-EPMC12314323 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature