Periostin is a Pivotal Target of microRNA-150-5p in Cardiac Fibroblast Activation and Chronic Myocardial Infarction.

ABSTRACT: Our prior studies have revealed that miR-150-5p (miR-150) attenuated cardiac dysfunction in mice, which overexpressed a long noncoding RNA called myocardial infarction-associated transcript during myocardial infarction or harbored cardiac-specific abrogation of β-arrestin-mediated β₁-adrenergic receptor signaling during chronic catecholamine stimulation. Although previous studies have shown the importance of miR-150 in heart failure, details surrounding its actions remain elusive in part because of (1) the lack of detailed mechanistic insight by which this small noncoding RNA induces myocardial protection and (2) the absence of definitive studies using appropriate mouse models to establish its direct functional relationship with key downstream targets. In the current study, we p

SUBMITTER: Hayasaka T 

PROVIDER: S-EPMC12314325 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature