Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors.

ABSTRACT: BACH1 is a transcriptional repressor that regulates oxidative stress and inflammatory responses and has emerged as a promising therapeutic target in cancer and other diseases. In lung cancer, BACH1 overexpression is linked to poor prognosis and metastasis, yet a consistent transcriptional signature reflecting its activity has not yet been defined. To address this, we performed RNA-Seq coupled with ChIP-Seq in BACH1-proficient and BACH1-deficient lung cancer cells, identifying a set of direct BACH1 target genes. This novel lung cancer BACH1 signature is highly sensitive and specific to BACH1 perturbation, unaffected by NRF2 modulation, and consistent across a large panel of cancer cell lines. Despite NRF2 binding to the same regions, BACH1-mediated gene repression is dominant over NRF2-driv

SUBMITTER: Klenja-Skudrinja D 

PROVIDER: S-EPMC12314328 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature