Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8⁺ T Cells Location.

ABSTRACT: CD8⁺ T cells are central to targeting and eliminating cancer cells. Their function is critically supported by type 1 conventional dendritic cells (cDC1s), which both prime antigen-specific CD8⁺ T cells in tumour-draining lymph nodes (tdLNs) and sustain primed CD8⁺ T cells within tumours. Despite their importance, the spatiotemporal organisation of cDC1s within tumours and their diverse functional roles remain poorly understood. Here, we use scRNAseq and unbiased spatial analysis to construct a detailed map of cDC1 states and distribution within immunogenic mouse tumours during CD8⁺ T-cell-mediated rejection. We reveal two distinct cDC1 activation states characterised by differential expression of genes linked to anti-tumour immunity, including Cx

SUBMITTER: Piot C 

PROVIDER: S-EPMC12314343 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature