Genome-wide association and linkage analysis of histidine-rich glycoprotein identifies common variants associated with plasma histidine-rich glycoprotein concentrations.

ABSTRACT:

Background

The plasma protein histidine-rich glycoprotein (HRG) interacts with multiple plasma ligands with various roles in coagulation, immunity, and angiogenesis. Through its inhibition of factor XIIa, HRG regulates the contact pathway of blood coagulation. Plasma HRG concentrations are highly heritable and vary widely, which may impact HRG function.

Objectives

To determine the genetic factors contributing to HRG variability.

Methods

Plasma HRG concentrations were measured in a healthy sibling cohort of 1152 subjects and a second healthy cohort of 2304 individuals of Irish descent. We performed genome-wide association study and meta-analysis on the European subset of these cohorts. Using the sibling subset of the 2 cohorts (n = 934 in 460 sibships), we explo

SUBMITTER: Underwood MI 

PROVIDER: S-EPMC12314372 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature