Radiomic Profiling of Tumor Thrombus for Predicting Recurrence in Renal Cell Carcinoma.

ABSTRACT:

Background and objective

Clear cell renal cell carcinoma (ccRCC) with tumor thrombus (TT) presents a significant prognostic challenge due to its high recurrence risk. Radiomics, an imaging-based biomarker approach, has primarily focused on the primary tumor, while the prognostic potential of TT radiomics remains largely unexplored. This study aimed to assess the added value of tumor thrombus radiomic signatures (RSs) in predicting recurrence in ccRCC patients with TT.

Methods

We conducted a retrospective analysis of patients undergoing surgical resection for nonmetastatic ccRCC with TT. Preoperative contrast-enhanced computed tomography images were used to extract radiomic features from the primary tumor and TT. Features were selected using least absolute shrinkage and selec

SUBMITTER: Khene ZE 

PROVIDER: S-EPMC12314389 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature