Deoxynucleosides as promising antimicrobial agents against foodborne pathogens and their applications in food and contact material surfaces.

ABSTRACT: V. parahaemolyticus biofilms accumulate on various seafoods and contact surfaces where they induce cross-contamination, spoilage and persistence in the food industry. Recently, nucleosides are being repurposed for antibacterial and technological applications including preservation and flavor enhancement. Therefore, for the first time, we explored the effects of various nucleosides against the biofilm and planktonic lifestyles of Vibrio spp, vis-à-vis the mechanisms, synergism with food additive, food and surface decontamination potentials. Among the sixty-six nucleosides evaluated, 2',3'-dideoxyadenosine (ddA) and 2'-deoxy-5-fluorocytidine (FdCyd) were identified as exceptional biofilm inhibitors, achieving 98 and 100 % reduction respectively. FdCyd exhibited low minimum inhi

SUBMITTER: Faleye OS 

PROVIDER: S-EPMC12314396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature