Risk Stratification and Prognosis Determination Based on Protein Lysine Crotonylation in Patients with Resected Pancreatic Cancer: A Multicenter Study.

ABSTRACT:

Purpose

Despite advances in neoadjuvant therapy and surgery, a limited increase in the 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) has occurred, implying the importance of postoperative management. This study aims to achieve risk stratification of patients with PDAC, providing guidance for clinicians to make better regimen choices and realizing precision treatment.

Experimental design

Five protein posttranslational modifications (PTM) were detected to find out the most prognostic marker using the IHC method. The predictive and prognostic performance of lysine pan-crotonylation (pan-Kcr) expression standing out from the initial selection was measured in the discovery cohort and validated in two independent cohorts. A risk stratification model

SUBMITTER: Cao L 

PROVIDER: S-EPMC12314513 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature