Early microglial and astrocyte reactivity in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

The role of neuroinflammation in preclinical Alzheimer's disease (AD) remains unclear.

Methods

We assessed changes in microglial and astrocytic biomarkers in a well-characterized cohort of 211 cognitively unimpaired individuals. Structural equation modeling was used to simultaneously assess all relationships among microglial and astrocytic responses and AD pathological events.

Results

Plasma glial fibrillary acidic protein (GFAP) and cerebrospinal fluid (CSF) soluble triggering receptor expressed on myeloid cells 2 (sTREM2) were increased in preclinical AD. Plasma GFAP showed an inverse bidirectional relationship with CSF amyloid beta (Aβ)42/40. CSF sTREM2 directly influenced CSF phosphorylated tau-181 (p-tau181) and neurogranin, and correlated with CSF S

SUBMITTER: Fernandez-Matarrubia M 

PROVIDER: S-EPMC12314543 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature