Predicting p53 Status in IDH-Mutant Gliomas Using MRI-Based Radiomic Model.

ABSTRACT:

Objectives

Accurate and noninvasive detection of p53 status in isocitrate dehydrogenase mutant (IDH-mt) glioma is clinically meaningful for molecular stratification of glioma, yet it remains challenging. We aimed to investigate the diagnostic efficacy of radiomics utilizing pre-surgery contrast-enhanced T1-weighted imaging (CE-T1WI) for predicting p53 status in IDH-mt gliomas.

Methods

A total of seventy-eight patients with pathologically confirmed IDH-mutant glioma were admitted to our institution between January 2011 and October 2018. For each patient, three types of volumes of interest (VOIs) were segmented: (i) VOI^T: the entire tumor (including the necrotic area within the tumor); (ii) VOI^PE: the peritumoral edema; (iii) VOI^T + PE: the ent

SUBMITTER: Li J 

PROVIDER: S-EPMC12314547 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature