Severe hepatitis in pediatric patients: The Severe Hepatitis In Pediatric Patients (SHIPP) registry.

ABSTRACT:

Objectives

Clusters of severe acute hepatitis in children were reported worldwide beginning in October 2021. Although most children recovered, some progressed to liver failure leading to death or liver transplantation. Herein, we characterize the clinical characteristics, and outcomes of this group of children through an international collaborative effort.

Methods

Participation was solicited via a global listserv to pediatric gastroenterologists worldwide. Patients <18 years, alanine aminotransferase >500 U/L, without chronic liver disease or acetaminophen ingestion were eligible. Data were submitted by individual sites into a Research Electronic Data Capture registry created in July 2022.

Results

Two hundred and seven cases were collected, with a peak incidence of 28

SUBMITTER: Kehar M 

PROVIDER: S-EPMC12314570 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature