Design, synthesis and biological evaluation of novel bis(indolyl)-tetrazine derivatives as anti-breast cancer agents.

ABSTRACT: A series of novel bis(indolyl)-tetrazine derivatives were designed and synthesized to develop potential anti-breast cancer agents. The compounds were characterized by spectral analysis using ¹H NMR, ¹³C NMR spectroscopy, and HRMS. Further, the structure of one of the derivatives 5b was confirmed by single crystal X-ray diffraction technique. The compounds exhibited good to moderate anti-proliferative activity against MCF-7 and MDA-MB-231 cell lines, showing IC₅₀ values of 7.57-22.52 μM and 10.08-21.49 μM, respectively. However, only four compounds, 5b, 5f, 5i, and 5j were found to be active against the T-47D cell line. Particularly, compounds 5b and 5f demonstrated the most promising anti-proliferative activity as compared to standard drug bazedoxifene (IC<

SUBMITTER: Kaur K 

PROVIDER: S-EPMC12314655 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature