Rethinking chromogranin A: unveiling gastrointestinal factors beyond neuroendocrine neoplasms-a narrative review.

ABSTRACT:

Background and objective

Chromogranin A (CgA) is extensively recognized as a biomarker in neuroendocrine neoplasms (NENs) due to its secretion alongside peptide hormones and biogenic amines in neuroendocrine cells. Despite its widespread clinical use, the reliability of CgA as a diagnostic and prognostic tool remains controversial because of its variable expression in various diseases and the influence of factors such as medication and disease characteristics. This review critically examines the role of CgA beyond neuroendocrine contexts, particularly in gastrointestinal conditions where increased levels may mislead clinical diagnostics.

Methods

This review was conducted by performing a search on the PubMed database regarding CgA and both pathological and non-pathological co

SUBMITTER: Romano E 

PROVIDER: S-EPMC12314672 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature