Chinese expert consensus on clinical diagnosis and treatment of breast cancer targeting HER2.

ABSTRACT:

Background

Human epidermal growth factor receptor 2 (HER2) is an important driver gene and prognostic indicator of breast cancer and also a key predictor of HER2-targeted therapies. Both the low expression and the positive expression of the HER2 protein are clinically significant for disease treatment and prognosis.

Methods

(I) Establishment of expert group: the expert group consists of experts from departments such as medical oncology, breast surgery, and pathology; (II) literature search: mainly conducted in English databases (such as PubMed, Embase, and Cochrane Library) with a search cutoff date of June 1, 2025; (III) assessment of evidence quality and recommendation strength: evidence quality and recommendation opinions are graded based on the evidence category and reco

SUBMITTER: Li J 

PROVIDER: S-EPMC12314674 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature