Long-term durability of infliximab maintenance therapy incorporating plant-based diet in inflammatory bowel disease.

ABSTRACT:

Background

The new therapeutic modality incorporating a countermeasure against a westernized diet, i.e., a plant-based diet, showed far better outcomes than current standards in inflammatory bowel disease (IBD). Infliximab is widely used for induction and subsequent scheduled maintenance therapy in patients with IBD. However, the efficacy of infliximab diminishes over time. In the present study, we investigated the durability of scheduled infliximab maintenance therapy incorporating plant-based diet in IBD.

Methods

This was a prospective single-group trial at tertiary hospitals. Infliximab maintenance therapy was indicated in patients with severe disease or those who were unresponsive to conventional therapy. Infliximab (5 mg/kg body weight) was infused every 8 weeks on an i

SUBMITTER: Chiba M 

PROVIDER: S-EPMC12314719 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature